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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1313752
Species: Homo sapiens
RGD Object: Gene
Symbol: TBK1
Name: TANK binding kinase 1
Acc ID: CHEBI:2922
Term: auranofin
Definition: An S-glycosyl compound consisting of 2,3,4,6-tetra-O-acetyl-1-thio-beta-D-glucopyranose with the sufur atom coordinated to (triethylphosphoranylidene)gold. It is administered orally for the treatment of active progressive rheumatoid arthritis.
Chemical ID: MESH:D001310
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TBK1multiple interactionsISOTbk1 (Mus musculus)6480464CTDAuranofin inhibits the reaction [TBK1 protein results in increased activity of IRF3 protein]PMID:17034761
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