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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708418
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cd40lg
Name: CD40 ligand
Acc ID: CHEBI:291902
Term: eptifibatide
Definition: A synthetic homodetic cyclic peptide comprising N(alpha)-(3-sulfanylpropanoyl)homoarginyl, glycyl, aspartyl, tryptophyl, prolyl and cysteinamide residues connected in sequence and cyclised via a disulfide bond. Derived from a protein found in the venom of the southeastern pygmy rattlesnake, Sistrurus miliarus barbouri, eptifibatide is an anti-coagulant that inhibits platelet aggregation by selectively blocking the platelet glycoprotein IIb/IIIa receptor, so preventing the binding of fibrinogen, von Willebrand factor, and other adhesive ligands. It is used in the management of unstable angina and in patients undergoing coronary angioplasty and stenting procedures.
Chemical ID: MESH:C086648
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:13529596480464CTDeptifibatide results in decreased expression of CD40LG protein

PMID:16391376
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.