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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736515
Species: Homo sapiens
RGD Object: Gene
Symbol: SOD3
Name: superoxide dismutase 3
Acc ID: CHEBI:29073
Term: L-ascorbic acid
Definition: The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.
Chemical ID: MESH:D001205
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SOD3multiple interactionsEXP 6480464CTDAscorbic Acid inhibits the reaction [Estradiol results in decreased expression of SOD3 mRNA]; Ascorbic Acid inhibits the reaction [Estradiol results in decreased expression of SOD3 protein]PMID:25130429
SOD3affects localizationISOSod3 (Rattus norvegicus)6480464CTDAscorbic Acid affects the localization of SOD3 proteinPMID:23027624
SOD3increases activityISOSod3 (Rattus norvegicus)6480464CTDAscorbic Acid results in increased activity of SOD3 proteinPMID:23027624
SOD3increases expressionISOSod3 (Rattus norvegicus)6480464CTDAscorbic Acid results in increased expression of SOD3 proteinPMID:23027624
SOD3multiple interactionsISOSod3 (Rattus norvegicus)6480464CTDAscorbic Acid inhibits the reaction [Estradiol inhibits the reaction [NFE2L2 protein binds to SOD3 promoter]]; Ascorbic Acid inhibits the reaction [Estradiol results in decreased activity of SOD3 protein]; Ascorbic Acid inhibits the reaction [Estradiol results in decreased expression of SOD3 mRNA]; Ascorbic Acid inhibits the reaction [Estradiol results in decreased expression of SOD3 protein]PMID:23027624
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