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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:29073
Term: L-ascorbic acid
Definition: The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.
Chemical ID: MESH:D001205
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDAscorbic Acid inhibits the reaction [Estradiol results in decreased expression of NQO1 mRNA], Ascorbic Acid inhibits the reaction [Estradiol results in decreased expression of NQO1 protein]

PMID:25130429
increases expressionISORGD:25036480464CTDAscorbic Acid results in increased expression of NQO1 protein

PMID:22008531
multiple interactionsISORGD:104736480464CTDAscorbic Acid promotes the reaction [sodium arsenite results in increased expression of NQO1 mRNA]

PMID:16517059
multiple interactionsISORGD:25036480464CTD[Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Diethylhexyl Phthalate results in increased expression of NQO1 protein], Ascorbic Acid promotes the reaction [Cadmium results in increased expression of NQO1 protein]

PMID:22008531, PMID:29663635
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.