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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734037
Species: Homo sapiens
RGD Object: Gene
Symbol: COL2A1
Name: collagen type II alpha 1 chain
Acc ID: CHEBI:29073
Term: L-ascorbic acid
Definition: The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.
Chemical ID: MESH:D001205
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
COL2A1multiple interactionsEXP 6480464CTD[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of COL2A1 mRNA; IL1B protein inhibits the reaction [[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of COL2A1 mRNA]; resveratrol inhibits the reaction [IL1B protein inhibits the reaction [[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of COL2A1 mRNA]]PMID:26526931
COL2A1increases expressionISOCol2a1 (Rattus norvegicus)6480464CTDAscorbic Acid results in increased expression of COL2A1 mRNAPMID:15372504
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