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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc23a2
Name: solute carrier family 23 member 2
Acc ID: CHEBI:29073
Term: L-ascorbic acid
Definition: The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.
Chemical ID: MESH:D001205
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc23a2decreases expressionEXP 6480464CTDAscorbic Acid results in decreased expression of SLC23A2 mRNAPMID:19418264
Slc23a2increases abundanceISOSlc23a2 (Mus musculus)6480464CTDSLC23A2 mRNA results in increased abundance of Ascorbic AcidPMID:22558179
Slc23a2increases expressionISOSlc23a2 (Mus musculus)6480464CTDAscorbic Acid deficiency results in increased expression of SLC23A2 protein; Ascorbic Acid results in increased expression of SLC23A2 mRNAPMID:20122894 PMID:22001929
Slc23a2multiple interactionsISOSLC23A2 (Homo sapiens)6480464CTDAscorbic Acid inhibits the reaction [nickel sulfate results in decreased expression of SLC23A2 mRNA]; Diclofenac inhibits the reaction [SLC23A2 protein results in increased uptake of Ascorbic Acid]; Estradiol inhibits the reaction [SLC23A2 protein results in increased uptake of Ascorbic Acid]; Genistein inhibits the reaction [SLC23A2 protein results in increased uptake of Ascorbic Acid]; Hydrocortisone inhibits the reaction [SLC23A2 protein results in increased uptake of Ascorbic Acid]; Indomethacin inhibits the reaction [SLC23A2 protein results in increased uptake of Ascorbic Acid]; Progesterone inhibits the reaction [SLC23A2 protein results in increased uptake of Ascorbic Acid]; Quercetin inhibits the reaction [SLC23A2 protein results in increased uptake of Ascorbic Acid]PMID:16288478 PMID:17092984
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