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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1617608
Species: Mus musculus
RGD Object: Gene
Symbol: Cxcl15
Name: C-X-C motif chemokine ligand 15
Acc ID: CHEBI:29073
Term: L-ascorbic acid
Definition: The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.
Chemical ID: MESH:D001205
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcl15affects expressionISOCXCL8 (Homo sapiens)6480464CTDAscorbic Acid affects the expression of CXCL8 mRNA; Ascorbic Acid deficiency affects the expression of CXCL8 mRNAPMID:19932582
Cxcl15multiple interactionsISOCXCL8 (Homo sapiens)6480464CTD[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with ferulic acid] inhibits the reaction [[Ozone co-treated with Oxygen] results in increased expression of CXCL8 mRNA]; [Ascorbic Acid co-treated with Lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of CXCL8 protein]; [Ascorbic Acid co-treated with Lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Ascorbic Acid affects the reaction [Homocysteine results in increased secretion of CXCL8 protein]; Ascorbic Acid affects the reaction [homocysteine thiolactone results in increased secretion of CXCL8 protein]; Ascorbic Acid inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of CXCL8 protein]; Ascorbic Acid inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]PMID:16715183 PMID:25551565 PMID:26270818
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