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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307751
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Srebf2
Name: sterol regulatory element binding transcription factor 2
Acc ID: CHEBI:29073
Term: L-ascorbic acid
Definition: The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.
Chemical ID: MESH:D001205
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Srebf2decreases metabolic processingISOSREBF2 (Homo sapiens)6480464CTDAscorbic Acid results in decreased metabolism of SREBF2 proteinPMID:32913121
Srebf2increases expressionISOSrebf2 (Mus musculus)6480464CTDAscorbic Acid results in increased expression of SREBF2 mRNAPMID:32913121
Srebf2multiple interactionsISOSREBF2 (Homo sapiens)6480464CTDSREBF2 protein affects the reaction [Ascorbic Acid results in increased expression of LDLR mRNA]; SREBF2 protein affects the reaction [Ascorbic Acid results in increased expression of LDLR protein]PMID:32913121
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