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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731289
Species: Homo sapiens
RGD Object: Gene
Symbol: ADRB1
Name: adrenoceptor beta 1
Acc ID: CHEBI:2904
Term: atenolol
Definition: An ethanolamine compound having a (4-carbamoylmethylphenoxy)methyl group at the 1-position and an N-isopropyl substituent.
Chemical ID: MESH:D001262
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects bindingEXP 6480464CTDAtenolol binds to ADRB1 protein

PMID:10372227, PMID:8386603
affects response to substanceEXP 6480464CTDADRB1 protein polymorphism affects the susceptibility to Atenolol

PMID:22192668
decreases activityEXP 6480464CTDAtenolol results in decreased activity of ADRB1 protein

PMID:1389726
multiple interactionsEXP 6480464CTD[Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein], [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein], [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein], [Atenolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP, [Atenolol binds to and results in decreased activity of ADRB1 protein] which results in decreased susceptibility to Nicotine, [Atenolol co-treated with ADRB1] results in increased abundance of Cyclic AMP, Atenolol binds to and results in decreased activity of ADRB1 protein, Atenolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP], Atenolol inhibits the reaction [CGP 12177 results in increased activity of ADRB1 protein], Atenolol inhibits the reaction [cyanopindolol binds to ADRB1 protein], Atenolol inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein]

PMID:12022239, PMID:12761341, PMID:14730417, PMID:15060759, PMID:17003101, PMID:17369603, PMID:8102213
affects bindingISORGD:20596480464CTDAtenolol binds to ADRB1 protein

PMID:11483288, PMID:2462161, PMID:9593075
decreases expressionISORGD:20596480464CTDAtenolol results in decreased expression of ADRB1 mRNA

PMID:17628611
multiple interactionsISORGD:20596480464CTDAtenolol binds to and results in decreased activity of ADRB1 protein, Atenolol inhibits the reaction [CGP 12177 binds to ADRB1 protein], Atenolol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]

PMID:10894789, PMID:11425575, PMID:2462161, PMID:2897299
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.