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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dhfr
Name: dihydrofolate reductase
Acc ID: CHEBI:29007
Term: ceftriaxone
Definition: A third-generation cephalosporin compound having 2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetylamino and [(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl side-groups.
Chemical ID: MESH:D002443
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dhfrdecreases activityISODHFR (Homo sapiens)6480464CTDCeftriaxone results in decreased activity of DHFR proteinPMID:25418905
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