Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68584
Species: Homo sapiens
RGD Object: Gene
Symbol: KCNH1
Name: potassium voltage-gated channel subfamily H member 1
Acc ID: CHEBI:2896
Term: astemizole
Definition: A piperidine compound having a 2-(4-methoxyphenyl)ethyl group at the 1-position and an N-[(4-fluorobenzyl)benzimidazol-2-yl]amino group at the 4-position.
Chemical ID: MESH:D016589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects bindingEXP 6480464CTDAstemizole binds to KCNH1 protein

PMID:18471075
decreases activityEXP 6480464CTDAstemizole results in decreased activity of KCNH1 protein

PMID:14985237, PMID:16816845, PMID:20050851
multiple interactionsEXP 6480464CTDAstemizole binds to and results in decreased activity of KCNH1 protein, Astemizole inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein]

PMID:17520698, PMID:18497958
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.