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RGD ID: 68584
Species: Homo sapiens
RGD Object: Gene
Symbol: KCNH1
Name: potassium voltage-gated channel subfamily H member 1
Acc ID: CHEBI:2896
Term: astemizole
Definition: A piperidine compound having a 2-(4-methoxyphenyl)ethyl group at the 1-position and an N-[(4-fluorobenzyl)benzimidazol-2-yl]amino group at the 4-position.
Chemical ID: MESH:D016589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects bindingEXP 6480464CTDAstemizole binds to KCNH1 protein

decreases activityEXP 6480464CTDAstemizole results in decreased activity of KCNH1 protein

PMID:14985237, PMID:16816845, PMID:20050851
multiple interactionsEXP 6480464CTDAstemizole binds to and results in decreased activity of KCNH1 protein, Astemizole inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein]

PMID:17520698, PMID:18497958
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.