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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731072
Species: Homo sapiens
RGD Object: Gene
Symbol: VEGFA
Name: vascular endothelial growth factor A
Acc ID: CHEBI:28955
Term: 2-methoxy-17beta-estradiol
Definition: A 17beta-hydroxy steroid, being 17beta-estradiol methoxylated at C-2.
Chemical ID: MESH:C022830
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
VEGFAdecreases expressionEXP 6480464CTD2-Methoxyestradiol results in decreased expression of VEGFA mRNA; 2-Methoxyestradiol results in decreased expression of VEGFA proteinPMID:26011145
VEGFAmultiple interactionsEXP 6480464CTD2-Methoxyestradiol promotes the reaction [Quercetin results in decreased expression of VEGFA mRNA]; 2-Methoxyestradiol promotes the reaction [Quercetin results in decreased expression of VEGFA protein]; Quercetin promotes the reaction [2-Methoxyestradiol results in decreased expression of VEGFA mRNA]; Quercetin promotes the reaction [2-Methoxyestradiol results in decreased expression of VEGFA protein]PMID:26011145
VEGFAaffects expressionISOVegfa (Rattus norvegicus)6480464CTD2-Methoxyestradiol affects the expression of VEGFA proteinPMID:21092735
VEGFAdecreases expressionISOVegfa (Rattus norvegicus)6480464CTD2-Methoxyestradiol results in decreased expression of VEGFA proteinPMID:31850806 PMID:32461003
VEGFAmultiple interactionsISOVegfa (Rattus norvegicus)6480464CTD2-Methoxyestradiol promotes the reaction [methylmercuric chloride results in decreased expression of VEGFA protein]; 2-Methoxyestradiol promotes the reaction [Methylmercury Compounds results in decreased expression of VEGFA protein]PMID:31850806 PMID:32461003
VEGFAmultiple interactionsISOVegfa (Mus musculus)6480464CTD2-Methoxyestradiol inhibits the reaction [Glucose results in increased expression of VEGFA protein]PMID:21617913
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