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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3757
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Srd5a1
Name: steroid 5 alpha-reductase 1
Acc ID: CHEBI:28952
Term: 5alpha-pregnane-3,20-dione
Definition: A C21-steroid hormone that is 5alpha-pregnane substituted by oxo groups at positions 3 and 20. It is a metabolite of progestrone.
Chemical ID: MESH:D043582
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases chemical synthesisISORGD:7364466480464CTDSRD5A1 protein results in increased chemical synthesis of 5-alpha-Dihydroprogesterone

PMID:25463305
multiple interactionsISORGD:7364466480464CTD[SRD5A1 protein results in increased metabolism of Progesterone] which results in increased chemical synthesis of 5-alpha-Dihydroprogesterone

PMID:23183084
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.