Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	619561
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	VDR
Name:	vitamin D receptor

Acc ID:	CHEBI:28940
Term:	calciol
Definition:	A hydroxy seco-steroid that is (5Z,7E)-9,10-secocholesta-5,7,10(19)-triene in which the pro-S hydrogen at position 3 has been replaced by a hydroxy group. It is the inactive form of vitamin D3, being hydroxylated in the liver to calcidiol (25-hydroxyvitamin D3), which is then further hydroxylated in the kidney to give calcitriol (1,25-dihydroxyvitamin D3), the active hormone.
Chemical ID:	MESH:D002762

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
VDR	affects localization	EXP		6480464	CTD	Cholecalciferol affects the localization of VDR protein	PMID:36066700
VDR	increases expression	EXP		6480464	CTD	Cholecalciferol results in increased expression of VDR; Cholecalciferol results in increased expression of VDR mRNA; Cholecalciferol results in increased expression of VDR protein	PMID:17024972 PMID:36066700
VDR	multiple interactions	EXP		6480464	CTD	[Cholecalciferol binds to VDR protein] which results in increased expression of SLCO1A2 mRNA; [Cholecalciferol co-treated with Tretinoin] promotes the reaction [[VDR protein binds to RXRA protein] which binds to SLCO1A2 promoter]; Aflatoxin B1 inhibits the reaction [Cholecalciferol affects the localization of VDR protein]; Aflatoxin B1 inhibits the reaction [Cholecalciferol results in increased expression of VDR mRNA]; Aflatoxin B1 inhibits the reaction [Cholecalciferol results in increased expression of VDR protein]; Cholecalciferol binds to and results in increased activity of VDR protein mutant form; Cholecalciferol inhibits the reaction [RXRA protein binds to VDR promoter]; Cholecalciferol promotes the reaction [[VDR protein binds to SLCO1A2 promoter] which results in increased expression of SLCO1A2 mRNA]; Cholecalciferol promotes the reaction [Fenretinide results in increased expression of VDR]; Cholecalciferol promotes the reaction [RARA protein binds to VDR enhancer]; Cholecalciferol promotes the reaction [RARA protein binds to VDR promoter]; Cholecalciferol promotes the reaction [RXRA protein binds to VDR enhancer]; Cholecalciferol promotes the reaction [VDR protein binds to SLCO1A2 promoter]; Cholecalciferol promotes the reaction [VDR protein binds to VDR enhancer]; VDR protein affects the reaction [Cholecalciferol results in increased expression of SLCO1A2 mRNA]	PMID:17024972 PMID:21397016 PMID:22474172 PMID:36066700
VDR	multiple interactions	ISO	Vdr (Mus musculus)	6480464	CTD	[bisphenol A co-treated with Cholecalciferol] results in increased expression of VDR mRNA; [bisphenol A co-treated with Cholecalciferol] results in increased expression of VDR protein; Cholecalciferol inhibits the reaction [[Hexachlorobenzene co-treated with Diethylnitrosamine] results in increased expression of VDR protein]; Cholecalciferol promotes the reaction [[RXRB protein binds to VDR protein] which binds to TNFSF11 promoter]	PMID:17008384 PMID:28634113 PMID:32702508
VDR	multiple interactions	ISO	Vdr (Rattus norvegicus)	6480464	CTD	Cholecalciferol inhibits the reaction [Dietary Fats results in decreased expression of VDR mRNA]; Cholecalciferol inhibits the reaction [Gentamicins results in decreased expression of VDR protein]	PMID:29653100 PMID:30458643

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