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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11429
Species: Mus musculus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:28940
Term: calciol
Definition: A hydroxy seco-steroid that is (5Z,7E)-9,10-secocholesta-5,7,10(19)-triene in which the pro-S hydrogen at position 3 has been replaced by a hydroxy group. It is the inactive form of vitamin D3, being hydroxylated in the liver to calcidiol (25-hydroxyvitamin D3), which is then further hydroxylated in the kidney to give calcitriol (1,25-dihydroxyvitamin D3), the active hormone.
Chemical ID: MESH:D002762
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfdecreases expressionEXP 6480464CTDCholecalciferol results in decreased expression of TNF mRNAPMID:16142846
Tnfmultiple interactionsEXP 6480464CTDCholecalciferol inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; Cholecalciferol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]PMID:16142846 PMID:33974900
Tnfdecreases expressionISOTNF (Homo sapiens)6480464CTDCholecalciferol results in decreased expression of TNF proteinPMID:28576736
Tnfmultiple interactionsISOTnf (Rattus norvegicus)6480464CTDCholecalciferol inhibits the reaction [Dietary Fats results in decreased expression of TNF mRNA]; Cholecalciferol inhibits the reaction [Dietary Fats results in increased expression of TNF protein]; Cholecalciferol inhibits the reaction [lead acetate results in increased expression of TNF protein]PMID:29653100 PMID:34051273
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