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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731513
Species: Mus musculus
RGD Object: Gene
Symbol: Eif2s1
Name: eukaryotic translation initiation factor 2, subunit 1 alpha
Acc ID: CHEBI:28939
Term: N-acetyl-L-cysteine
Definition: An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.
Chemical ID: MESH:D000111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eif2s1multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased phosphorylation of EIF2S1 protein]; Acetylcysteine inhibits the reaction [Indican results in increased phosphorylation of EIF2S1 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased phosphorylation of EIF2S1 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of EIF2S1 protein]PMID:21911445 PMID:27709270 PMID:29380555 PMID:31330229
Eif2s1multiple interactionsISOEif2s1 (Rattus norvegicus)6480464CTDAcetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of EIF2S1 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of EIF2S1 protein]; Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased expression of EIF2S1 protein modified form]PMID:16324875 PMID:24291486 PMID:27484784
Eif2s1multiple interactionsISOEIF2S1 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Acrylamide results in increased phosphorylation of EIF2S1 protein]; Acetylcysteine inhibits the reaction [chrysophanic acid results in increased phosphorylation of EIF2S1 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased phosphorylation of EIF2S1 protein]; Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of EIF2S1 protein]; Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased phosphorylation of EIF2S1 protein]PMID:15788408 PMID:25568320 PMID:27634458 PMID:27816613 PMID:30300626 PMID:32506763
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