GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CYP1A1 | increases expression | EXP | | 6480464 | CTD | Acetylcysteine results in increased expression of CYP1A1 protein | PMID:35123993 | CYP1A1 | multiple interactions | EXP | | 6480464 | CTD | [Acetylcysteine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]] which results in decreased expression of NQO1 mRNA; Acetylcysteine affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]]; Acetylcysteine inhibits the reaction [1-(4-chlorophenyl)-benzo-2,5-quinone results in increased expression of CYP1A1 mRNA]; Acetylcysteine inhibits the reaction [2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]]; Acetylcysteine inhibits the reaction [hydroquinone results in increased expression of CYP1A1 protein]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CYP1A1 mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CYP1A1 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of CYP1A1 mRNA]; Acetylcysteine inhibits the reaction [sodium arsenite inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of CYP1A1 mRNA]; Acetylcysteine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Acetylcysteine promotes the reaction [Particulate Matter results in increased expression of CYP1A1 mRNA] | PMID:15044633 PMID:19033395 PMID:20801209 PMID:21703343 PMID:25668756 PMID:26535918 PMID:27041069 PMID:29753051 PMID:30793600 PMID:34171359 PMID:35123993 | CYP1A1 | multiple interactions | ISO | Cyp1a1 (Mus musculus) | 6480464 | CTD | [Acetylcysteine co-treated with 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide] inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]; Acetylcysteine affects the reaction [andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]]; Acetylcysteine affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Acetylcysteine inhibits the reaction [Benzo(a)pyrene results in decreased activity of CYP1A1 protein]; Acetylcysteine inhibits the reaction [beta-Naphthoflavone results in decreased activity of CYP1A1 protein]; Acetylcysteine inhibits the reaction [chromium trioxide results in increased expression of CYP1A1 mRNA]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of CYP1A1 mRNA]; Acetylcysteine promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein] | PMID:15621696 PMID:16274885 PMID:21094198 PMID:29975444 PMID:30793600 | CYP1A1 | multiple interactions | ISO | Cyp1a1 (Rattus norvegicus) | 6480464 | CTD | [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in increased expression of CYP1A1 mRNA; Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of CYP1A1 mRNA] | PMID:22129741 PMID:30639957 | | ||||||||||||||||||||||
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