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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69171
Species: Mus musculus
RGD Object: Gene
Symbol: Ucp2
Name: uncoupling protein 2 (mitochondrial, proton carrier)
Acc ID: CHEBI:28939
Term: N-acetyl-L-cysteine
Definition: An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.
Chemical ID: MESH:D000111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ucp2multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [Doxorubicin results in decreased expression of UCP2 mRNA]; Acetylcysteine inhibits the reaction [Doxorubicin results in decreased expression of UCP2 protein]PMID:29061315
Ucp2multiple interactionsISOUcp2 (Rattus norvegicus)6480464CTDAcetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of UCP2 mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of UCP2 protein]; Acetylcysteine inhibits the reaction [pirinixic acid results in increased expression of UCP2 protein]PMID:18183618 PMID:30104959 PMID:36493885
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