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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69169
Species: Mus musculus
RGD Object: Gene
Symbol: Pparg
Name: peroxisome proliferator activated receptor gamma
Acc ID: CHEBI:28939
Term: N-acetyl-L-cysteine
Definition: An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.
Chemical ID: MESH:D000111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargmultiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [[Carbon Monoxide results in increased abundance of Reactive Oxygen Species] which results in increased sumoylation of PPARG protein]; Acetylcysteine inhibits the reaction [INS1 protein results in increased expression of PPARG protein]PMID:22046279 PMID:27117918
Ppargincreases expressionISOPparg (Rattus norvegicus)6480464CTDAcetylcysteine results in increased expression of PPARG mRNA; Acetylcysteine results in increased expression of PPARG proteinPMID:17602960
Ppargmultiple interactionsISOPparg (Rattus norvegicus)6480464CTDAcetylcysteine inhibits the reaction [yttrium chloride results in decreased expression of PPARG protein]; Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in increased expression of PPARG mRNA]; Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in increased expression of PPARG protein]PMID:17602960 PMID:35088107
Ppargmultiple interactionsISOPPARG (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [[[15-deoxyprostaglandin J2 results in increased activity of PPARG protein] which results in decreased expression of SOD2 protein] which results in increased abundance of Reactive Oxygen Species]; Acetylcysteine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PPARG protein]PMID:16945329 PMID:23964924
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