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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3852
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tgfbr1
Name: transforming growth factor, beta receptor 1
Acc ID: CHEBI:28939
Term: N-acetyl-L-cysteine
Definition: An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.
Chemical ID: MESH:D000111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfbr1decreases expressionEXP 6480464CTDAcetylcysteine results in decreased expression of TGFBR1 mRNA; Acetylcysteine results in decreased expression of TGFBR1 proteinPMID:17602960
Tgfbr1multiple interactionsEXP 6480464CTDButhionine Sulfoximine inhibits the reaction [Acetylcysteine results in decreased expression of TGFBR1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in decreased expression of TGFBR1 protein]PMID:17602960
Tgfbr1multiple interactionsISOTGFBR1 (Homo sapiens)6480464CTD[Acetylcysteine co-treated with Cadmium] results in decreased expression of TGFBR1 mRNA; Acetylcysteine inhibits the reaction [[Cadmium Chloride co-treated with sodium arsenite] results in increased expression of TGFBR1 mRNA]; Acetylcysteine inhibits the reaction [Water Pollutants, Chemical results in increased expression of TGFBR1 mRNA]PMID:29408318
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