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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3771
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stat1
Name: signal transducer and activator of transcription 1
Acc ID: CHEBI:28939
Term: N-acetyl-L-cysteine
Definition: An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.
Chemical ID: MESH:D000111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of STAT1 protein]

PMID:17607690
multiple interactionsISORGD:7321846480464CTDAcetylcysteine inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT1 protein]], Acetylcysteine inhibits the reaction [nickel sulfate results in increased phosphorylation of STAT1 protein], Acetylcysteine inhibits the reaction [Ozone results in increased phosphorylation of STAT1 protein]

PMID:16896058, PMID:19061877, PMID:20525893
multiple interactionsISORGD:7321856480464CTDAcetylcysteine inhibits the reaction [15-deoxy-delta(12, 14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]], Acetylcysteine promotes the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]

PMID:12847270
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.