GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Sod2 | multiple interactions | EXP | | 6480464 | CTD | Acetylcysteine inhibits the reaction [Atorvastatin results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [bisphenol A results in increased acetylation of SOD2 protein]; Acetylcysteine inhibits the reaction [Chlorpyrifos results in decreased expression of SOD2 protein]; Acetylcysteine inhibits the reaction [Glucose results in decreased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [Glucose results in decreased expression of SOD2 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased activity of SOD2 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased acetylation of SOD2 protein]; Acetylcysteine inhibits the reaction [Monocrotophos results in decreased expression of SOD2 mRNA] | PMID:21775390 PMID:22714038 PMID:23159718 PMID:30104959 PMID:30641872 PMID:35403558 | Sod2 | increases expression | ISO | Sod2 (Mus musculus) | 6480464 | CTD | Acetylcysteine results in increased expression of SOD2 mRNA; Acetylcysteine results in increased expression of SOD2 protein | PMID:17010595 | Sod2 | increases expression | ISO | SOD2 (Homo sapiens) | 6480464 | CTD | Acetylcysteine results in increased expression of SOD2 mRNA; Acetylcysteine results in increased expression of SOD2 protein | PMID:7476933 | Sod2 | multiple interactions | ISO | Sod2 (Mus musculus) | 6480464 | CTD | [Acetylcysteine results in increased expression of SOD2 protein] which results in decreased abundance of Reactive Oxygen Species; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of SOD2 protein]; Acetylcysteine inhibits the reaction [Cyclosporine results in decreased expression of SOD2 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased expression of SOD2 protein]; Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of SOD2 protein]; Acetylcysteine promotes the reaction [Oxygen results in increased expression of SOD2 mRNA]; Acetylcysteine promotes the reaction [Oxygen results in increased expression of SOD2 protein] | PMID:17010595 PMID:22718889 PMID:23765110 PMID:28499986 PMID:29111403 | Sod2 | multiple interactions | ISO | SOD2 (Homo sapiens) | 6480464 | CTD | [Acetylcysteine co-treated with IL1A protein] results in increased expression of SOD2 protein; [Acetylcysteine co-treated with TNF protein] results in increased expression of SOD2 protein; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] which results in decreased expression of SOD2 mRNA; Acetylcysteine affects the reaction [SOD2 protein affects the activity of CASP9 protein]; Acetylcysteine affects the reaction [SOD2 protein results in decreased susceptibility to Doxorubicin]; Acetylcysteine affects the reaction [SOD2 protein results in decreased susceptibility to Paclitaxel]; Acetylcysteine inhibits the reaction [[[15-deoxyprostaglandin J2 results in increased activity of PPARG protein] which results in decreased expression of SOD2 protein] which results in increased abundance of Reactive Oxygen Species]; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD2 protein]; Acetylcysteine inhibits the reaction [[Hydrogen Peroxide co-treated with Nitroprusside] results in increased expression of SOD2 protein]; Acetylcysteine inhibits the reaction [Antimycin A results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 protein]; Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [Glucose deficiency affects the folding of SOD2 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of SOD2 protein]; Acetylcysteine inhibits the reaction [linsidomine results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of SOD2 protein]; Acetylcysteine inhibits the reaction [Norepinephrine results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [Peroxynitrous Acid results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [Rotenone results in increased expression of and results in increased activity of SOD2 protein]; Acetylcysteine inhibits the reaction [Rotenone results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [Rotenone results in increased expression of SOD2 protein]; Acetylcysteine inhibits the reaction [SOD2 protein affects the activity of AR protein]; Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of AKR1C3 mRNA]; Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of AMACR mRNA]; Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of ESR1 mRNA]; Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of ESR2 mRNA]; Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of FKBP5 mRNA]; Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of HSD11B2 mRNA]; Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of HSD17B8 mRNA]; Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of KLK3 mRNA]; Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of PGR mRNA]; Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of RXRA mRNA]; Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of TMPRSS2 mRNA]; Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of VEGFA mRNA]; Acetylcysteine inhibits the reaction [TGFB1 protein results in decreased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [TNF protein results in increased expression of SOD2 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased expression of SOD2]; Acetylcysteine promotes the reaction [Eugenol results in decreased expression of SOD2 mRNA]; Acetylcysteine promotes the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Acetylcysteine promotes the reaction [TNF protein results in increased expression of SOD2 mRNA]; TNF protein promotes the reaction [Acetylcysteine results in increased expression of SOD2 mRNA] | PMID:11264281 PMID:12031898 PMID:15904944 PMID:16101137 PMID:17309078 PMID:18594523 PMID:18829485 PMID:20674559 PMID:21131394 PMID:22429591 PMID:23114885 PMID:23964924 PMID:32023790 PMID:32092105 PMID:35430258 PMID:7476933 PMID:8760145 PMID:9535218 PMID:9741582 | | ||||||||||||||||||||||
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