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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3387
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prkaa1
Name: protein kinase AMP-activated catalytic subunit alpha 1
Acc ID: CHEBI:28939
Term: N-acetyl-L-cysteine
Definition: An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.
Chemical ID: MESH:D000111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prkaa1multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [Cadmium Chloride results in decreased phosphorylation of PRKAA1 protein]PMID:21195169
Prkaa1multiple interactionsISOPRKAA1 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Cadmium Chloride results in decreased phosphorylation of PRKAA1 protein]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased phosphorylation of PRKAA1 protein]; Acetylcysteine inhibits the reaction [dorsomorphin results in decreased expression of PRKAA1 mRNA]; Acetylcysteine inhibits the reaction [Quercetin results in increased phosphorylation of and results in increased activity of PRKAA1 protein]; Acetylcysteine inhibits the reaction [Quercetin results in increased phosphorylation of PRKAA1 protein]; Acetylcysteine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased phosphorylation of PRKAA1 protein]PMID:19293639 PMID:20083342 PMID:21195169 PMID:24386346 PMID:24535669 PMID:31900833 PMID:36534932
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