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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2323
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdkn2a
Name: cyclin-dependent kinase inhibitor 2A
Acc ID: CHEBI:28939
Term: N-acetyl-L-cysteine
Definition: An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.
Chemical ID: MESH:D000111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn2amultiple interactionsISOCdkn2a (Mus musculus)6480464CTDAcetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of CDKN2A protein]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CDKN2A mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CDKN2A protein]PMID:31551408 PMID:32473187
Cdkn2amultiple interactionsISOCDKN2A (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] inhibits the reaction [DNMT1 protein binds to CDKN2A promoter]]; Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] inhibits the reaction [EZH2 protein binds to CDKN2A promoter]]; Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] promotes the reaction [KDM2A protein binds to CDKN2A promoter]]; Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] promotes the reaction [TET1 protein binds to CDKN2A promoter]]; Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of CDKN2A protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of CDKN2A mRNA]; IL7R mRNA alternative form promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of CDKN2A mRNA]]PMID:31551408 PMID:35303175
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