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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1342674
Species: Homo sapiens
RGD Object: Gene
Symbol: PPARGC1A
Name: PPARG coactivator 1 alpha
Acc ID: CHEBI:28939
Term: N-acetyl-L-cysteine
Definition: An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.
Chemical ID: MESH:D000111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PPARGC1Amultiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [Flavonoids results in increased expression of PPARGC1A protein]; Acetylcysteine inhibits the reaction [Polystyrenes analog results in decreased expression of PPARGC1A protein]PMID:23063593 PMID:37084995
PPARGC1Amultiple interactionsISOPpargc1a (Rattus norvegicus)6480464CTDAcetylcysteine inhibits the reaction [Atorvastatin results in increased expression of PPARGC1A mRNA]; Acetylcysteine inhibits the reaction [bisphenol A results in decreased expression of PPARGC1A protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of PPARGC1A mRNA]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of PPARGC1A protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of PPARGC1A protein]; Acetylcysteine inhibits the reaction [Monocrotophos results in decreased expression of PPARGC1A mRNA]; Acetylcysteine inhibits the reaction [sodium bisulfite results in decreased expression of PPARGC1A mRNA]PMID:21775390 PMID:26980303 PMID:30104959 PMID:30641872 PMID:35403558 PMID:36493885
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