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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1315044
Species: Mus musculus
RGD Object: Gene
Symbol: Map3k5
Name: mitogen-activated protein kinase kinase kinase 5
Acc ID: CHEBI:28939
Term: N-acetyl-L-cysteine
Definition: An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.
Chemical ID: MESH:D000111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map3k5multiple interactionsISOMAP3K5 (Homo sapiens)150429751RGDN-acetyl-L-cysteine co-treated with Curcumin increases phosphorylation of MAP3K5 protein in uterine cervix 
Map3k5multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [Rotenone inhibits the reaction [TXN protein binds to and results in decreased activity of MAP3K5 protein]]PMID:16449798
Map3k5multiple interactionsISOMap3k5 (Rattus norvegicus)6480464CTDAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP3K5 protein]PMID:18703135
Map3k5multiple interactionsISOMAP3K5 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [bisphenol A results in increased phosphorylation of MAP3K5 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP3K5 protein]; Acetylcysteine inhibits the reaction [platycodin D affects the phosphorylation of and results in increased activity of MAP3K5 protein]; Acetylcysteine inhibits the reaction [Quercetin results in decreased phosphorylation of and results in increased activity of MAP3K5 protein]PMID:18703135 PMID:20083342 PMID:22784044 PMID:33039870
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