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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305471
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atf6
Name: activating transcription factor 6
Acc ID: CHEBI:28939
Term: N-acetyl-L-cysteine
Definition: An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.
Chemical ID: MESH:D000111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atf6multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of ATF6 protein modified form]; Acetylcysteine inhibits the reaction [arsenite results in increased expression of ATF6 protein]; Acetylcysteine inhibits the reaction [gadolinium chloride results in increased expression of ATF6 protein]PMID:18077580 PMID:21198628 PMID:24291486
Atf6multiple interactionsISOATF6 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [hydroquinone results in decreased expression of ATF6 protein]; Acetylcysteine inhibits the reaction [Sodium Selenite results in increased expression of ATF6 protein]; Acetylcysteine results in increased metabolism of and results in increased activity of ATF6 proteinPMID:19722195 PMID:34520753 PMID:37148176
Atf6multiple interactionsISOAtf6 (Mus musculus)6480464CTDAcetylcysteine inhibits the reaction [chloroacetic acid results in increased cleavage of ATF6 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased cleavage of ATF6 protein]; Acetylcysteine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of ATF6 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of ATF6 protein]PMID:21911445 PMID:25451595 PMID:31330229 PMID:37692514
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