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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11276
Species: Mus musculus
RGD Object: Gene
Symbol: Ccl3
Name: C-C motif chemokine ligand 3
Acc ID: CHEBI:28939
Term: N-acetyl-L-cysteine
Definition: An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.
Chemical ID: MESH:D000111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl3decreases secretionEXP 6480464CTDAcetylcysteine results in decreased secretion of CCL3 proteinPMID:28555929
Ccl3multiple interactionsEXP 6480464CTD[Acetylcysteine co-treated with Particulate Matter] results in increased secretion of CCL3 protein; Acetylcysteine inhibits the reaction [Paraquat results in increased expression of CCL3 mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of CCL3 mRNA]; Acetylcysteine promotes the reaction [Polymyxin B inhibits the reaction [Particulate Matter results in increased secretion of CCL3 protein]]; Acetylcysteine promotes the reaction [Polymyxin B results in decreased secretion of CCL3 protein]; MYD88 protein affects the reaction [[Acetylcysteine co-treated with Particulate Matter] results in increased secretion of CCL3 protein]; Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of CCL3 mRNA]]; Polymyxin B promotes the reaction [Acetylcysteine results in decreased secretion of CCL3 protein]PMID:21765237 PMID:28555929
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