GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nqo1 | multiple interactions | EXP | | 6480464 | CTD | [Acetylcysteine co-treated with chromium trioxide] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of NQO1 protein]; Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NQO1 mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased expression of NQO1 mRNA]; Acetylcysteine inhibits the reaction [Cadmium Chloride promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of NQO1 protein]]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased activity of NQO1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of NQO1 mRNA]; Acetylcysteine inhibits the reaction [Copper Sulfate results in increased expression of NQO1 mRNA]; Acetylcysteine inhibits the reaction [Copper Sulfate results in increased expression of NQO1 protein]; Acetylcysteine inhibits the reaction [Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NQO1 mRNA]]; Acetylcysteine inhibits the reaction [Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NQO1 protein]]; Acetylcysteine inhibits the reaction [sodium arsenite promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of NQO1 protein]]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased activity of NQO1 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of NQO1 mRNA]; Acetylcysteine promotes the reaction [Benzo(a)pyrene results in increased expression of NQO1 protein] | PMID:16274885 PMID:21533816 PMID:21569840 PMID:31029725 PMID:37353053 PMID:37598416 | Nqo1 | increases expression | ISO | Nqo1 (Rattus norvegicus) | 6480464 | CTD | Acetylcysteine results in increased expression of NQO1 mRNA; Acetylcysteine results in increased expression of NQO1 protein | PMID:30633982 | Nqo1 | multiple interactions | ISO | Nqo1 (Rattus norvegicus) | 6480464 | CTD | [Acetylcysteine co-treated with Sodium Fluoride] results in increased expression of NQO1 mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of NQO1 mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NQO1 protein]; Acetylcysteine promotes the reaction [Sodium Fluoride results in increased expression of NQO1 protein] | PMID:22129741 PMID:30104959 PMID:30633982 | Nqo1 | multiple interactions | ISO | NQO1 (Homo sapiens) | 6480464 | CTD | [Acetylcysteine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]] which results in decreased expression of NQO1 mRNA; Acetylcysteine inhibits the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 mRNA]; Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of NQO1 mRNA]; Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of NQO1 protein]; Acetylcysteine inhibits the reaction [Antimycin A results in increased expression of NQO1 mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of NQO1 protein]; Acetylcysteine inhibits the reaction [Aspirin analog results in increased activity of NQO1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of NQO1 mRNA]; Acetylcysteine inhibits the reaction [diallyl trisulfide results in increased expression of NQO1 protein]; Acetylcysteine inhibits the reaction [Dinitrochlorobenzene results in increased expression of NQO1 mRNA]; Acetylcysteine inhibits the reaction [Mercury results in increased expression of NQO1 mRNA]; Acetylcysteine inhibits the reaction [NQO1 protein results in increased susceptibility to 9,10-phenanthrenequinone]; Acetylcysteine inhibits the reaction [Particulate Matter analog results in increased expression of NQO1 mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter analog results in increased expression of NQO1 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of NQO1 mRNA]; Acetylcysteine inhibits the reaction [pterostilbene results in increased expression of NQO1 mRNA]; Acetylcysteine inhibits the reaction [sodium arsenite promotes the reaction [NFE2L2 protein binds to NQO1 promoter]]; Acetylcysteine inhibits the reaction [sulforaphane results in increased expression of NQO1 mRNA]; Acetylcysteine inhibits the reaction [tetrabromobisphenol A results in increased expression of NQO1 mRNA]; Acetylcysteine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]; Acetylcysteine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions analog results in increased expression of NQO1 mRNA]; Acetylcysteine inhibits the reaction [Vehicle Emissions analog results in increased expression of NQO1 protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of NQO1 mRNA]; NQO1 protein promotes the reaction [Acetylcysteine results in decreased susceptibility to 9,10-phenanthrenequinone] | PMID:12730081 PMID:15044633 PMID:16920990 PMID:19033392 PMID:22925602 PMID:23035985 PMID:24489685 PMID:24646717 PMID:25003661 PMID:25341683 PMID:25980575 PMID:26600472 PMID:29108775 PMID:30309986 PMID:30951941 PMID:32525552 PMID:35430258 | |
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