GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | PTGS2 | increases expression | ISO | Ptgs2 (Rattus norvegicus) | 6480464 | CTD | Mechlorethamine results in increased expression of PTGS2 mRNA; Mechlorethamine results in increased expression of PTGS2 protein | PMID:20883710 PMID:26273949 PMID:28184907 | PTGS2 | increases expression | ISO | Ptgs2 (Mus musculus) | 6480464 | CTD | Mechlorethamine results in increased expression of PTGS2; Mechlorethamine results in increased expression of PTGS2 mRNA; Mechlorethamine results in increased expression of PTGS2 protein | PMID:24631667 PMID:25891025 PMID:34453837 PMID:35998709 | PTGS2 | multiple interactions | ISO | Ptgs2 (Rattus norvegicus) | 6480464 | CTD | Valproic Acid inhibits the reaction [Mechlorethamine results in increased expression of PTGS2 mRNA] | PMID:28184907 | PTGS2 | multiple interactions | ISO | Ptgs2 (Mus musculus) | 6480464 | CTD | KIT gene mutant form inhibits the reaction [Mechlorethamine results in increased expression of PTGS2 mRNA]; MPO gene mutant form inhibits the reaction [Mechlorethamine results in increased expression of PTGS2]; NR1H4 protein affects the reaction [Mechlorethamine results in increased expression of PTGS2 protein] | PMID:24631667 PMID:34453837 PMID:35998709 | | ||||||||||||||||||||||
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