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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737501
Species: Homo sapiens
RGD Object: Gene
Symbol: PKM
Name: pyruvate kinase M1/2
Acc ID: CHEBI:28918
Term: (R)-adrenaline
Definition: The R-enantiomer of adrenaline. It is a hormone secreted by the adrenal glands resulting in the 'fight-or-flight' response.
Chemical ID: MESH:D004837
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PKMincreases expressionEXP 6480464CTDEpinephrine results in increased expression of PKM proteinPMID:36423730
PKMincreases expressionISOPkm (Mus musculus)6480464CTDEpinephrine results in increased expression of PKM proteinPMID:36423730
PKMmultiple interactionsISOPkm (Rattus norvegicus)6480464CTD[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PKM proteinPMID:19464573
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