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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732861
Species: Homo sapiens
RGD Object: Gene
Symbol: CHEK2
Name: checkpoint kinase 2
Acc ID: CHEBI:28901
Term: busulfan
Definition: A methanesulfonate ester that is butane-1,4-diol in which the hydrogens of the hydroxy groups are replaced by methanesulfonyl groups. An alkylating antineoplastic agent, it is used for the treatment of chronic myeloid leukemia (although it has been largely replaced by newer drugs). It is also used as an insect sterilant.
Chemical ID: MESH:D002066
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CHEK2multiple interactionsEXP 6480464CTD[clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of CHEK2 proteinPMID:20933509
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