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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69096
Species: Mus musculus
RGD Object: Gene
Symbol: Tgfb1
Name: transforming growth factor, beta 1
Acc ID: CHEBI:28901
Term: busulfan
Definition: A methanesulfonate ester that is butane-1,4-diol in which the hydrogens of the hydroxy groups are replaced by methanesulfonyl groups. An alkylating antineoplastic agent, it is used for the treatment of chronic myeloid leukemia (although it has been largely replaced by newer drugs). It is also used as an insect sterilant.
Chemical ID: MESH:D002066
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfb1increases expressionISOTGFB1 (Homo sapiens)6480464CTDBusulfan results in increased expression of TGFB1 mRNAPMID:22286157 PMID:37597760
Tgfb1multiple interactionsISOTGFB1 (Homo sapiens)6480464CTDpirfenidone inhibits the reaction [Busulfan results in increased expression of TGFB1 mRNA]PMID:37597760
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