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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732909
Species: Homo sapiens
RGD Object: Gene
Symbol: AKT1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:28885
Term: butan-1-ol
Definition: A primary alcohol that is butane in which a hydrogen of one of the methyl groups is substituted by a hydroxy group. It it produced in small amounts in humans by the gut microbes.
Chemical ID: MESH:D020001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AKT1multiple interactionsEXP 6480464CTD1-Butanol inhibits the reaction [P2RY1 protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; 1-Butanol inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein]; [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of AKT1 mRNAPMID:15919668 PMID:16236484 PMID:29432896
AKT1multiple interactionsISOAkt1 (Rattus norvegicus)6480464CTD1-Butanol inhibits the reaction [AGT protein results in increased phosphorylation of AKT1 protein]; 1-Butanol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of AKT1 protein]; 1-Butanol inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of AKT1 protein]PMID:14769825 PMID:15525798 PMID:15705590
AKT1multiple interactionsISOAkt1 (Mus musculus)6480464CTD1-Butanol inhibits the reaction [Phospholipids results in increased phosphorylation of AKT1 protein]PMID:15956784
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