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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10510
Species: Mus musculus
RGD Object: Gene
Symbol: Egf
Name: epidermal growth factor
Acc ID: CHEBI:28885
Term: butan-1-ol
Definition: A primary alcohol that is butane in which a hydrogen of one of the methyl groups is substituted by a hydroxy group. It it produced in small amounts in humans by the gut microbes.
Chemical ID: MESH:D020001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:25426480464CTD1-Butanol inhibits the reaction [EGF protein binds to and results in increased degradation of EGFR protein], 1-Butanol inhibits the reaction [EGF protein binds to and results in increased localization of EGFR protein], 1-Butanol inhibits the reaction [EGF protein results in increased abundance of Phosphatidic Acids], 1-Butanol inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein], 1-Butanol inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]

PMID:11134345
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.