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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69328
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdkn1a
Name: cyclin-dependent kinase inhibitor 1A
Acc ID: CHEBI:28869
Term: menadione
Definition: A member of the class of 1,4-naphthoquinones that is 1,4-naphthoquinone which is substituted at position 2 by a methyl group. It is used as a nutritional supplement and for the treatment of hypoprothrombinemia.
Chemical ID: MESH:D024483
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1aincreases expressionISOCDKN1A (Homo sapiens)6480464CTDVitamin K 3 results in increased expression of CDKN1A mRNA; Vitamin K 3 results in increased expression of CDKN1A proteinPMID:12414654 PMID:23410634 PMID:25005833
Cdkn1amultiple interactionsISOCDKN1A (Homo sapiens)6480464CTD[sodium arsenite co-treated with Vitamin K 3] results in increased expression of CDKN1A protein; EUK-134 affects the reaction [Vitamin K 3 results in increased expression of CDKN1A protein]; SB 203580 inhibits the reaction [[sodium arsenite co-treated with Vitamin K 3] results in increased expression of CDKN1A protein]PMID:19082730 PMID:25005833
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