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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:28869
Term: menadione
Definition: A member of the class of 1,4-naphthoquinones that is 1,4-naphthoquinone which is substituted at position 2 by a methyl group. It is used as a nutritional supplement and for the treatment of hypoprothrombinemia.
Chemical ID: MESH:D024483
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxaffects localizationEXP 6480464CTDVitamin K 3 affects the localization of BAX proteinPMID:15961378
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDVitamin K 3 results in increased expression of BAX proteinPMID:25005833
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDEUK-134 inhibits the reaction [Vitamin K 3 results in increased expression of BAX protein]PMID:25005833
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