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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1349499
Species: Homo sapiens
RGD Object: Gene
Symbol: UGT1A6
Name: UDP glucuronosyltransferase family 1 member A6
Acc ID: CHEBI:28869
Term: menadione
Definition: A member of the class of 1,4-naphthoquinones that is 1,4-naphthoquinone which is substituted at position 2 by a methyl group. It is used as a nutritional supplement and for the treatment of hypoprothrombinemia.
Chemical ID: MESH:D024483
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
UGT1A6increases activityISOUgt1a6 (Rattus norvegicus)6480464CTDVitamin K 3 results in increased activity of UGT1A6 promoterPMID:15336321
UGT1A6increases expressionISOUgt1a6 (Rattus norvegicus)6480464CTDVitamin K 3 results in increased expression of UGT1A6 mRNAPMID:15336321 PMID:22846377
UGT1A6multiple interactionsISOUgt1a6 (Rattus norvegicus)6480464CTDAcetylcysteine inhibits the reaction [Vitamin K 3 results in increased activity of UGT1A6 promoter]PMID:15336321
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