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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732911
Species: Mus musculus
RGD Object: Gene
Symbol: Cdkn1a
Name: cyclin dependent kinase inhibitor 1A
Acc ID: CHEBI:28863
Term: flavanones
Definition: Members of the class of flavans with a 3,4-dihydro-2-aryl-2H-1-benzopyran-4-one skeleton and its substituted derivatives.
Chemical ID: MESH:D044950
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1adecreases response to substanceISOCDKN1A (Homo sapiens)6480464CTDCDKN1A protein results in decreased susceptibility to FlavanonesPMID:21616090
Cdkn1aincreases expressionISOCDKN1A (Homo sapiens)6480464CTDFlavanones results in increased expression of CDKN1A proteinPMID:21616090
Cdkn1amultiple interactionsISOCDKN1A (Homo sapiens)6480464CTDCDKN1A gene mutant form promotes the reaction [Flavanones results in increased cleavage of CASP7 protein]; CDKN1A gene mutant form promotes the reaction [Flavanones results in increased phosphorylation of H2AX protein]PMID:21616090
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