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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344192
Species: Homo sapiens
RGD Object: Gene
Symbol: TNF
Name: tumor necrosis factor
Acc ID: CHEBI:28854
Term: 2,4-D
Definition: A chlorophenoxyacetic acid that is phenoxyacetic acid in which the ring hydrogens at postions 2 and 4 are substituted by chlorines.
Chemical ID: MESH:D015084
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TNFincreases expressionISOTnf (Mus musculus)6480464CTD2,4-Dichlorophenoxyacetic Acid results in increased expression of TNF; 2,4-Dichlorophenoxyacetic Acid results in increased expression of TNF proteinPMID:20728597 PMID:35099110
TNFincreases expressionISOTnf (Rattus norvegicus)6480464CTD2,4-Dichlorophenoxyacetic Acid results in increased expression of TNF proteinPMID:34464015
TNFmultiple interactionsISOTnf (Mus musculus)6480464CTD2,4-Dichlorophenoxyacetic Acid inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in increased expression of TNF mRNA]; lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of TNF protein]PMID:35099110 PMID:37516258
TNFmultiple interactionsISOTnf (Rattus norvegicus)6480464CTD[2,4-dichlorophenoxyacetic acid isooctyl ester results in increased abundance of 2,4-Dichlorophenoxyacetic Acid] promotes the reaction [Ethanol results in increased expression of TNF mRNA]; [2,4-dichlorophenoxyacetic acid isooctyl ester results in increased abundance of 2,4-Dichlorophenoxyacetic Acid] which results in increased expression of TNF mRNA; Ethanol promotes the reaction [[2,4-dichlorophenoxyacetic acid isooctyl ester results in increased abundance of 2,4-Dichlorophenoxyacetic Acid] which results in increased expression of TNF mRNA]; lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of TNF protein]PMID:34464015 PMID:36085217
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