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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1346751
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP2B6
Name: cytochrome P450 family 2 subfamily B member 6
Acc ID: CHEBI:28851
Term: phenanthrene
Definition: A polycyclic aromatic hydrocarbon composed of three fused benzene rings which takes its name from the two terms 'phenyl' and 'anthracene.'
Chemical ID: MESH:C031181
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP2B6increases expressionEXP 6480464CTDphenanthrene results in increased expression of CYP2B6 mRNAPMID:31181217
CYP2B6increases expressionISOCyp2b10 (Mus musculus)6480464CTDphenanthrene results in increased expression of CYP2B10 mRNA; phenanthrene results in increased expression of CYP2B10 proteinPMID:31181217
CYP2B6multiple interactionsISOCyp2b10 (Mus musculus)6480464CTDNR1I3 gene mutant form inhibits the reaction [phenanthrene results in increased expression of CYP2B10 mRNA]; NR1I3 gene mutant form inhibits the reaction [phenanthrene results in increased expression of CYP2B10 protein]PMID:31181217
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