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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730901
Species: Homo sapiens
RGD Object: Gene
Symbol: HMOX1
Name: heme oxygenase 1
Acc ID: CHEBI:28834
Term: deoxycholic acid
Definition: A bile acid that is 5beta-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 12 respectively.
Chemical ID: MESH:D003840
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HMOX1decreases response to substanceEXP 6480464CTDHMOX1 protein results in decreased susceptibility to Deoxycholic AcidPMID:21362092
HMOX1increases expressionEXP 6480464CTDDeoxycholic Acid results in increased expression of HMOX1 mRNAPMID:32661532
HMOX1multiple interactionsEXP 6480464CTD[Cyclosporine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of HMOX1 mRNA; MTF1 protein affects the reaction [Deoxycholic Acid results in increased expression of HMOX1 mRNA]PMID:32152650 PMID:32661532
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