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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rela
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:28834
Term: deoxycholic acid
Definition: A bile acid that is 5beta-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 12 respectively.
Chemical ID: MESH:D003840
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Reladecreases response to substanceISORELA (Homo sapiens)6480464CTDRELA protein results in decreased susceptibility to Deoxycholic AcidPMID:12507930
Relaincreases expressionISORELA (Homo sapiens)6480464CTDDeoxycholic Acid results in increased expression of RELA proteinPMID:17644113
Relaincreases localizationISORELA (Homo sapiens)6480464CTDDeoxycholic Acid results in increased localization of RELA proteinPMID:17644113
Relamultiple interactionsISORELA (Homo sapiens)6480464CTDbenzyloxycarbonyl-isoleucyl-glutamyl(O-tert-butyl)-alanyl-leucinal inhibits the reaction [Deoxycholic Acid results in increased localization of RELA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Deoxycholic Acid results in increased localization of RELA protein]; lactacystin inhibits the reaction [Deoxycholic Acid results in increased localization of RELA protein]PMID:17644113
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