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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 71101
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc3
Name: ATP binding cassette subfamily C member 3
Acc ID: CHEBI:28834
Term: deoxycholic acid
Definition: A bile acid that is 5beta-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 12 respectively.
Chemical ID: MESH:D003840
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc3affects expressionISOAbcc3 (Mus musculus)6480464CTDDeoxycholic Acid affects the expression of ABCC3 mRNAPMID:21914718
Abcc3decreases expressionISOAbcc3 (Mus musculus)6480464CTDDeoxycholic Acid results in decreased expression of ABCC3 mRNAPMID:25582706
Abcc3increases activityISOABCC3 (Homo sapiens)6480464CTDDeoxycholic Acid results in increased activity of ABCC3 proteinPMID:17569508
Abcc3increases expressionISOABCC3 (Homo sapiens)6480464CTDDeoxycholic Acid results in increased expression of ABCC3 mRNAPMID:25055961
Abcc3multiple interactionsISOABCC3 (Homo sapiens)6480464CTD[Cyclosporine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of ABCC3 mRNA; [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt] results in decreased expression of ABCC3 mRNA; [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen] results in decreased expression of ABCC3 mRNA; [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine] results in decreased expression of ABCC3 mRNA; [nefazodone co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of ABCC3 mRNAPMID:32152650 PMID:33819548
Abcc3multiple interactionsISOAbcc3 (Mus musculus)6480464CTDSLCO1A1 protein affects the susceptibility to [Deoxycholic Acid affects the expression of ABCC3 mRNA]PMID:21914718
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