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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631400
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpbar1
Name: G protein-coupled bile acid receptor 1
Acc ID: CHEBI:28834
Term: deoxycholic acid
Definition: A bile acid that is 5beta-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 12 respectively.
Chemical ID: MESH:D003840
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gpbar1affects bindingISOGPBAR1 (Homo sapiens)6480464CTDDeoxycholic Acid binds to GPBAR1 proteinPMID:23566200
Gpbar1increases expressionISOGPBAR1 (Homo sapiens)6480464CTDDeoxycholic Acid results in increased expression of GPBAR1 mRNAPMID:25055961
Gpbar1increases response to substanceISOGpbar1 (Mus musculus)6480464CTDGPBAR1 protein results in increased susceptibility to Deoxycholic AcidPMID:23041323
Gpbar1multiple interactionsISOGpbar1 (Mus musculus)6480464CTDDeoxycholic Acid binds to and results in increased activity of GPBAR1 proteinPMID:23041323
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