GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nr1h4 | decreases expression | EXP | | 6480464 | CTD | Deoxycholic Acid results in decreased expression of NR1H4 mRNA | PMID:27743861 | Nr1h4 | multiple interactions | EXP | | 6480464 | CTD | [Cholic Acids co-treated with Deoxycholic Acid] results in decreased expression of NR1H4 mRNA | PMID:28391356 | Nr1h4 | increases activity | ISO | NR1H4 (Homo sapiens) | 6480464 | CTD | Deoxycholic Acid results in increased activity of NR1H4 protein | PMID:17567710 PMID:22561792 PMID:27871908 | Nr1h4 | increases activity | ISO | Nr1h4 (Mus musculus) | 6480464 | CTD | Deoxycholic Acid results in increased activity of NR1H4 protein | PMID:22531947 | Nr1h4 | increases expression | ISO | NR1H4 (Homo sapiens) | 6480464 | CTD | Deoxycholic Acid results in increased expression of NR1H4 mRNA; Deoxycholic Acid results in increased expression of NR1H4 protein | PMID:14684751 PMID:25055961 | Nr1h4 | multiple interactions | ISO | NR1H4 (Homo sapiens) | 6480464 | CTD | [[Deoxycholic Acid results in increased activity of NR1H4 protein] which binds to FGF19 promoter] which results in increased expression of FGF19 mRNA; [Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of NR1H4 mRNA; [Cyclosporine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of NR1H4 mRNA; [Deoxycholic Acid results in increased activity of NR1H4 protein] which binds to FGF19 promoter; [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen] results in decreased expression of NR1H4 mRNA; [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine] results in decreased expression of NR1H4 mRNA; [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Triclosan] results in decreased expression of NR1H4 mRNA; [nefazodone co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of NR1H4 mRNA; Deoxycholic Acid analog binds to and results in increased activity of NR1H4 protein; Deoxycholic Acid binds to and results in increased activity of NR1H4 protein; Deoxycholic Acid inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein] | PMID:13130122 PMID:22561792 PMID:25257666 PMID:32152650 PMID:33819548 | Nr1h4 | multiple interactions | ISO | Nr1h4 (Mus musculus) | 6480464 | CTD | [Deoxycholic Acid results in increased activity of NR1H4 protein] which results in increased expression of CYP7A1 mRNA | PMID:22531947 | |
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