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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2886
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il10
Name: interleukin 10
Acc ID: CHEBI:28834
Term: deoxycholic acid
Definition: A bile acid that is 5beta-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 12 respectively.
Chemical ID: MESH:D003840
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il10decreases abundanceISOIl10 (Mus musculus)6480464CTDIL10 gene mutant form results in decreased abundance of Deoxycholic AcidPMID:27580383
Il10increases expressionISOIl10 (Mus musculus)6480464CTDDeoxycholic Acid results in increased expression of IL10 mRNAPMID:23911798
Il10multiple interactionsISOIl10 (Mus musculus)6480464CTDDeoxycholic Acid promotes the reaction [irinotecan results in decreased secretion of IL10 protein]PMID:26706406
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