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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3112
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc1
Name: ATP binding cassette subfamily C member 1
Acc ID: CHEBI:28830
Term: chlorambucil
Definition: A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Chemical ID: MESH:D002699
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc1affects exportISOABCC1 (Homo sapiens)6480464CTDABCC1 protein affects the export of Chlorambucil analogPMID:11115505 PMID:14569069
Abcc1decreases response to substanceISOABCC1 (Homo sapiens)6480464CTDABCC1 protein results in decreased susceptibility to ChlorambucilPMID:10900222 PMID:11115505
Abcc1increases response to substanceISOABCC1 (Homo sapiens)6480464CTDABCC1 protein results in increased susceptibility to ChlorambucilPMID:12504668
Abcc1multiple interactionsISOABCC1 (Homo sapiens)6480464CTDbuthionine sulfoximine ethyl ester promotes the reaction [ABCC1 protein results in increased susceptibility to Chlorambucil]; GSTP1 protein promotes the reaction [ABCC1 protein results in decreased susceptibility to Chlorambucil]PMID:10900222 PMID:12504668
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