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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:28830
Term: chlorambucil
Definition: A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Chemical ID: MESH:D002699
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDChlorambucil results in decreased expression of BCL2 mRNA; Chlorambucil results in decreased expression of BCL2 proteinPMID:11699414 PMID:8822937
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTDIL4 protein inhibits the reaction [Chlorambucil results in decreased expression of BCL2 protein]PMID:8822937
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