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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731579
Species: Homo sapiens
RGD Object: Gene
Symbol: HMGCR
Name: 3-hydroxy-3-methylglutaryl-CoA reductase
Acc ID: CHEBI:28824
Term: stigmasterol
Definition: A 3beta-sterol that consists of 3beta-hydroxystigmastane having double bonds at the 5,6- and 22,23-positions.
Chemical ID: MESH:D013265
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HMGCRincreases expressionEXP 6480464CTDStigmasterol results in increased expression of HMGCR mRNAPMID:23454145
HMGCRmultiple interactionsEXP 6480464CTD[Stigmasterol co-treated with KNG1 protein modified form] results in increased expression of HMGCR mRNA; [Stigmasterol co-treated with Oligomycins] results in decreased expression of HMGCR mRNA; [Stigmasterol co-treated with Rotenone] results in decreased expression of HMGCR mRNAPMID:23454145
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